The Progress Towards the Synthesis of a Biofunctionalized Rotaxane

Rotaxanes have shown application as molecular machines due to their unique mechanically interlocked structures. It is this unique characteristic that leads to the attempt at synthesizing a biofunctionalized rotaxane. As protein function relies heavily on its structure, it is hoped that by utilizing the mechanically interlocked system allosteric control of the protein could be achieved. Several constraints need to be addressed before a biofunctionalized rotaxane can be successfully synthesized. This thesis reports advances into the synthesis of a biofunctionalized rotaxane.