The Propagation of Epileptiform Events Across the Corpus Callosum

Bisecting the corpus callosum, the primary fiber tract connecting the two cerebral hemispheres, has proven to be an effective palliative treatment for intractable epilepsy. The roots of this effectiveness are poorly understood. What role does the corpus callosum play in the propagation of seizures? We have developed a novel in vitro model for studying the role of the corpus callosum in the spread of seizures. What follows is a report of the refinement of a slice preparation designed to conserve the connections mediating the transcallosal propagation of epileptiform activity, and some preliminary findings regarding that propagation.