Publication Date

April 2015

Advisor(s)

Rex Pratt

Major

Chemistry

Language

English (United States)

Abstract

β-lactam antibiotics are commonly used in clinical practices to prevent bacterial infection. However, the efficacy of β-lactam antibiotics is threatened by β-lactamases. Although β-lactamases have traditionally been inhibited by β-lactam derivatives, increased bacterial resistance has made it necessary to search for non β-lactam inhibitors of β-lactamases. A variety of O-aryloxycarbonyl oximes were designed and synthesized as potential inhibitors of the class C β-lacatamase of Enterobacter cloacae P99. Through kinetics studies, it was established that these compounds, to various degrees, acted as irreversible inhibitors of β-lactamase. The results were compared with those previously obtained in this laboratory for O-aryloxycarbonyl hydroxamates.

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