Chemistry

Discovering the role of carbohydrate binding in cell recognition by Vibrio cholerae cytolysin

Sophia Rose Levan — Tue, 19 Jun 2012 09:15:21 PDT

The Role of H2A.Z in Chromosome Segregation in Saccharomyces cerevisiae

Dessislava Ioji Stefanova — Tue, 19 Jun 2012 09:13:18 PDT

Spectroscopic and Computational Studies of Gas Phase Hydrogen Bound Clusters of 9-Hydroxy-9H-Fluorene-9-Carboxylic Acid

Thomas Matthew Kuntz — Tue, 19 Jun 2012 09:06:19 PDT

The Anodic Oxidation of Diphenylacetaldehyde in the Presence of Alcohols

Rachel Leah Merzel — Tue, 19 Jun 2012 09:01:36 PDT

Building a Toolbox to Investigate Chromosome Dynamics of Meiotic Prophase

Sarah Rachael Beattie — Tue, 19 Jun 2012 08:44:49 PDT

Signaling to Sir2-mediated transcriptional silencing through metabolims

Kuan-lin Huang — Tue, 19 Jun 2012 08:41:02 PDT

An exploration of adjacent gene pairing in budding yeast and other eukaryotes

Sara Kass-Gergi — Tue, 19 Jun 2012 08:40:08 PDT

Synthesis and Analysis of Novel Mandelamide Hydrolase Substrates

Charles Abram Baron — Tue, 19 Jun 2012 08:30:18 PDT

Mapping of the SecA-SecG Protein Interface by Site-Directed in vivo Photo-Crosslinking

Jessica Ekema Chukwu — Thu, 02 Jun 2011 13:30:45 PDT

A Conserved Motif in EL4b of NSS Transporters May Control Antidepressant Binding

Michael Vincent LeVine — Thu, 02 Jun 2011 13:29:14 PDT

Computational and Spectroscopic Investigations of Reversible Furan-Maleimide Cycloadditions: Parent Reaction and Derivatized Analogues.

Robert Charles Boutelle — Thu, 02 Jun 2011 13:27:36 PDT

Synthesis of a Furan-Substituted Crown Ether Macrocycle and Applications in Host-Guest and Dynamic Diels-Alder Self-Assembling Systems.

Sarah Langlois White — Thu, 02 Jun 2011 13:09:36 PDT

Developing a Novel Fluorescent Reporter to Monitor Conformational Change of MutS, a Mismatch Repair Protein

Christopher William Doucette — Thu, 02 Jun 2011 13:04:21 PDT

Binding Parameters of Integration Host Factor to Four-Way Holliday Junction DNA

Olga Buzovetsky — Thu, 17 Jun 2010 11:35:01 PDT

Previous work in the Mukerji lab, characterized the binding properties of structurally similar but sequence non-specific DNA-binding protein HU, to duplex and Holliday junction DNA (4WJ). This research demonstrated that HU binds the central region of the 4WJ with nanomolar affinity and prefers the stacked form of the 4WJ with two HU dimers binding one junction. Given the similarities in structure and function of HU and IHF, we elected to study the binding affinity of IHF to the 4WJ. We have compared the IHF binding affinity for 4WJ DNA relative to that of duplex DNA with and without a consensus sequence. We determined that IHF has a 1:1 binding stoichiometry to the 4WJ. All binding assays established that IHF binds to the 4WJ lacking a consensus sequence with 2 nM KD. Moreover, anisotropy binding measurements demonstrated that IHF binds to the 4WJ with similar affinity as to H1 duplex DNA.

Fourier Transform Microwave Spectroscopy Investigation of Neon Cyanocyclobutane

William Githuku Ndugire — Thu, 17 Jun 2010 11:34:22 PDT

Characterizing the Lipopolysaccharide of V. cholerae to develop novel drug treatments

Colleen Antonette Carpenter — Thu, 17 Jun 2010 11:34:17 PDT

I. Stereochemistry of the stepwise oxidation of tris[4-propylthiophenyl]amine II. Synthesis of Triphenylamine Electrocatalysts: Nitration of tris[4-propylsulfonylphenyl]amine

Ernest Ignacy Sliwinski — Thu, 17 Jun 2010 11:34:06 PDT

Structural Energetics of a RNA-DNA Hybrid Containing a Tract of rA-dT Base Pairs

Katherine Leon — Thu, 17 Jun 2010 11:33:55 PDT

Conversion to Laser Vaporization for Gas Phase Spectroscopy

Eric Peter Boon — Thu, 17 Jun 2010 11:33:52 PDT

The scientific community has built models of molecular behavior that have increased in complexity as they increase in size. These models are confirmed by experimentation. As the scale at which models are accurate has increased, so too has there been an increase in the size of the molecules whose properties need to be investigated. In the field of gas phase spectroscopy, laser vaporization makes it possible for larger molecules to be investigated. This experiment seeks to convert a ZEKE/MATI/REMPI spectrometer from thermal vaporization to laser ablation. Methods for sample preparation and the laser ablation process were developed and tested using the molecule 9-Hydroxy-9-fluorenecarboxylic acid. This methodology produces wavelength dependent spectrum, but the shot-to-shot fluctuations continue to limit the applicability of this method to other molecules.

Exploring the Chemical and Biological Nature of Sonic Hedgehog Dependent Cell Proliferation

Samuel Max Cohen — Thu, 17 Jun 2010 11:32:26 PDT